Regioselective metal-free one-pot synthesis of functionalized 2-aminothiophene derivatives.
J Org Chem
; 80(9): 4611-7, 2015 May 01.
Article
en En
| MEDLINE
| ID: mdl-25880135
ABSTRACT
A facile metal-free synthesis of 2-aminothiophene derivatives by the reaction of 2-ynals with thioamides in alcohols has been developed. This transformation allows the assembly of 2-aminothienyl ether derivatives via a well-designed aldol condensation/regioselective intramolecular cyclization/conjugate addition cascade reaction and provides a straightforward synthetic protocol for constructing 2,3,5-trisubstituted 2-aminothiophenes.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tioamidas
/
Tiofenos
/
Alquinos
Idioma:
En
Revista:
J Org Chem
Año:
2015
Tipo del documento:
Article