A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis.
World J Surg Oncol
; 13: 67, 2015 Feb 21.
Article
en En
| MEDLINE
| ID: mdl-25889621
ABSTRACT
BACKGROUND:
IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz's disease, is characterized by elevated serum IgG4 and infiltration of IgG4-positive plasma cells in glandular tissues. Recently, several studies reported both malignant lymphoma developed on the background of IgG4-associated conditions and IgG4-producing malignant lymphoma (non-IgG4-related disease). CASE PRESENTATION We report on the case of a 70-year-old man who was strongly suspected IgG4-DS because of high serum IgG4 concentration (215 mg/dl) and bilateral swelling of parotid and submandibular glands. Biopsies of cervical lymph node and a portion of submandibular gland were performed. These histopathological findings subsequently confirmed a diagnosis of marginal zone B cell lymphoma.CONCLUSION:
Differential diagnosis of IgG4-DS is necessary from other disorders, including Sjögren's syndrome, sarcoidosis, Castleman's disease, Wegener's granulomatosis, lymphoma, and cancer. We suggest that biopsy of swollen lesions is important for a definitive diagnosis of IgG4-DS and discuss the mechanism of development in this case.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sialadenitis
/
Inmunoglobulina G
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Síndrome de Sjögren
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Granulomatosis con Poliangitis
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Enfermedad de Castleman
/
Linfoma de Células B de la Zona Marginal
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Dacriocistitis
/
Enfermedad de Mikulicz
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
World J Surg Oncol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Japón