Ferret airway epithelial cell cultures support efficient replication of influenza B virus but not mumps virus.
J Gen Virol
; 96(8): 2092-2098, 2015 Aug.
Article
en En
| MEDLINE
| ID: mdl-25953915
ABSTRACT
Ferrets have become the model animal of choice for influenza pathology and transmission experiments as they are permissive and susceptible to human influenza A viruses. However, inoculation of ferrets with mumps virus (MuV) did not lead to successful infections. We evaluated the use of highly differentiated ferret tracheal epithelium cell cultures, FTE, for predicting the potential of ferrets to support respiratory viral infections. FTE cultures supported productive replication of human influenza A and B viruses but not of MuV, whereas analogous cells generated from human airways supported replication of all three viruses. We propose that in vitro strategies using these cultures might serve as a method of triaging viruses and potentially reducing the use of ferrets in viral studies.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
Problema de salud:
2_enfermedades_transmissibles
Asunto principal:
Virus de la Influenza B
/
Tráquea
/
Replicación Viral
/
Células Epiteliales
/
Gripe Humana
/
Hurones
/
Virus de la Parotiditis
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Gen Virol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Reino Unido