CI-924 effects on plasma lipids in patients with type II and type IV hyperlipoproteinaemia.
Eur J Clin Pharmacol
; 37(5): 477-81, 1989.
Article
en En
| MEDLINE
| ID: mdl-2598985
ABSTRACT
CI-924 (CI), 5,5'-[[1,1'-biphenyl]-2,5-diylbis(oxy)]bis[2,2- dimethylpentanoic acid] is chemically similar to gemfibrozil. Patients with Type II (n = 13) and Type IV (n = 22) hyperlipoproteinaemia (HLP) were maintained 12 weeks on a baseline diet containing 55% sugar, 15% protein 30% fat and less than 300 mg cholesterol daily to stabilize weight and lipids. They were then entered in a parallel group double-blinded protocol and received 0, 300, 600, or 1200 mg CI p.o. daily for 12 weeks. CI consistently elevated anti-atherogenic HDL and lowered VLDL at 600 mg/day in both Type II and Type IV HPL at 8 weeks. In Type II patients, CI lowered cholesterol, decreased LDL/HDL and increased ApoA-I. In Type IV patients, CI also lowered TC while elevating LDL and ApoA-II. CI had no effect on Apo-B, LDL-ApoB, or Apo-E.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Gemfibrozilo
/
Hiperlipoproteinemia Tipo II
/
Hiperlipoproteinemia Tipo IV
/
Lípidos
/
Hipolipemiantes
Tipo de estudio:
Clinical_trials
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur J Clin Pharmacol
Año:
1989
Tipo del documento:
Article