Transcription factor genes essential for cell proliferation and replicative lifespan in budding yeast.
Biochem Biophys Res Commun
; 463(3): 351-6, 2015 Jul 31.
Article
en En
| MEDLINE
| ID: mdl-26022127
ABSTRACT
Many of the lifespan-related genes have been identified in eukaryotes ranging from the yeast to human. However, there is limited information available on the longevity genes that are essential for cell proliferation. Here, we investigated whether the essential genes encoding DNA-binding transcription factors modulated the replicative lifespan of Saccharomyces cerevisiae. Heterozygous diploid knockout strains for FHL1, RAP1, REB1, and MCM1 genes showed significantly short lifespan. (1)H-nuclear magnetic resonance analysis indicated a characteristic metabolic profile in the Δfhl1/FHL1 mutant. These results strongly suggest that FHL1 regulates the transcription of lifespan related metabolic genes. Thus, heterozygous knockout strains could be the potential materials for discovering further novel lifespan genes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Saccharomyces cerevisiae
/
Factores de Transcripción
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Proteínas de Saccharomyces cerevisiae
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Proteína 1 de Mantenimiento de Minicromosoma
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Proteínas de Unión a Telómeros
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Proteínas de Unión al ADN
/
Factores de Transcripción Forkhead
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
2015
Tipo del documento:
Article
País de afiliación:
Japón