Antioxidant Defense System after Single and Chronic Administration of Obestatin and Its Fragment (1-4) to Normal and Overweight Male Rats.
Bull Exp Biol Med
; 159(1): 38-40, 2015 May.
Article
en En
| MEDLINE
| ID: mdl-26033586
ABSTRACT
We studied the effects of anorectic peptide obestatin and its fragment (1-4) on the antioxidant defense system in animals with normal and experimentally induced increased body weight. In rats with normal body weight, no changes in activity of the antioxidant defense system 1 week after single administration of the substances. After chronic administration of obestatin and fragment (1-4) for 1 week, total antioxidant capacity of the plasma decreased; obestatin also lowered the content of TBA-reactive products. In the overweight rats, SOD-like activity in the plasma increased 1 week after chronic administration of obestatin. Hence, obestatin and its fragment (1-4) induced changes in the antioxidant defense system only after chronic administration.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Depresores del Apetito
/
Hormonas Peptídicas
/
Sobrepeso
/
Antioxidantes
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2015
Tipo del documento:
Article