Synthesis of (+)-Antroquinonol: An Antihyperglycemic Agent.

Sulake, Rohidas S; Lin, Hsiao-Han; Hsu, Chia-Yu; Weng, Ching-Feng; Chen, Chinpiao

Sulake, Rohidas S; Lin, Hsiao-Han; Hsu, Chia-Yu; Weng, Ching-Feng; Chen, Chinpiao.

Afiliación

Sulake RS; Department of Chemistry, National Dong Hwa University, Hualien 97401, Taiwan.
Lin HH; Department of Chemistry, National Dong Hwa University, Hualien 97401, Taiwan.
Hsu CY; Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan.
Weng CF; Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan.
Chen C; Department of Chemistry, National Dong Hwa University, Hualien 97401, Taiwan.

J Org Chem ; 80(12): 6044-51, 2015 Jun 19.

Article en En | MEDLINE | ID: mdl-26039178

RESUMEN

The total synthesis of antroquinonol has been accomplished through Suzuki-Miyaura cross-coupling and Barton-McCombie reaction, and the α,ß-unsaturation was achieved through selenylation and oxidation protocols. In vitro and in vivo studies on the glucose-lowering properties of antroquinonol indicate that it is a potential antidiabetic agent.

Asunto(s)

Hipoglucemiantes/síntesis química; Ubiquinona/análogos & derivados; Hipoglucemiantes/química; Hipoglucemiantes/farmacología; Espectroscopía de Resonancia Magnética; Estructura Molecular; Oxidación-Reducción; Ubiquinona/síntesis química; Ubiquinona/química; Ubiquinona/farmacología

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ubiquinona / Hipoglucemiantes Idioma: En Revista: J Org Chem Año: 2015 Tipo del documento: Article País de afiliación: Taiwán

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