Regulation of cough by neuronal Na(+)-K(+) ATPases.
Curr Opin Pharmacol
; 22: 140-5, 2015 Jun.
Article
en En
| MEDLINE
| ID: mdl-26048736
ABSTRACT
The Na(+)-K(+) ATPases play an essential role in establishing the sodium gradients in excitable cells. Multiple isoforms of the sodium pumps have been identified, with tissue and cell specific expression patterns. Because the vagal afferent nerves regulating cough must be activated at sustained high frequencies of action potential patterning to achieve cough initiation thresholds, it is a certainty that sodium pump function is essential to maintaining cough reflex sensitivities in health and in disease. The mechanisms by which Na(+)-K(+) ATPases regulate bronchopulmonary vagal afferent nerve excitability are reviewed as are potential therapeutic strategies targeting the sodium pumps in cough.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sodio
/
ATPasa Intercambiadora de Sodio-Potasio
/
Tos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Pharmacol
Asunto de la revista:
FARMACOLOGIA
Año:
2015
Tipo del documento:
Article