Candidate HLA genes for prediction of co-trimoxazole-induced severe cutaneous reactions.
Pharmacogenet Genomics
; 25(8): 402-11, 2015 Aug.
Article
en En
| MEDLINE
| ID: mdl-26086150
ABSTRACT
BACKGROUND:
Co-trimoxazole is a sulfonamide-containing antibiotic that is effective in the treatment of several infections and for prophylaxis of Pneumocystis jiroveci pneumonia. This drug has been reported as a common culprit drug for the Stevens-Johnson syndrome (SJS) and for toxic epidermal necrolysis (TEN). Human leukocyte antigens (HLAs) play a key role in the immunopathogenesis of severe cutaneous reactions induced by several drugs. This study investigated the association between the HLA class I and HLA-DRB1 polymorphisms and co-trimoxazole-induced SJS/TEN in a Thai population.METHODS:
Forty-three patients with co-trimoxazole-induced SJS/TEN and 91 co-trimoxazole-tolerant patients were enrolled in the study. HLA class I and HLA-DRB1 were genotyped using the reverse sequence-specific oligonucleotide probe method.RESULTS:
The frequencies of three alleles of HLA, namely HLA-B*1502, HLA-C*0602, and HLA-C*0801, were significantly higher in the co-trimoxazole-induced SJS/TEN group compared with controls. The risks for co-trimoxazole-induced SJS/TEN in patients with the HLA-B*1502, HLA-C*0602, or HLA-C*0801 allele were about 3-11-fold higher when compared with those who did not carry one of these alleles. Individuals who carried the HLA-B*1502-C*0801 haplotype had a 14-fold higher risk for co-trimoxazole-induced SJS/TEN.CONCLUSION:
Evidence of associations between co-trimoxazole-induced SJS/TEN and HLA alleles including HLA-B*1502, HLA-C*0602, and HLA-C*0801 were found in the study population. These findings may suggest that apart from the HLA molecules, other molecules involved in the molecular pathogenesis of these severe cutaneous adverse drug reactions may play an important role in the susceptibility of individuals to SJS/TEN caused by co-trimoxazole.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Combinación Trimetoprim y Sulfametoxazol
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Síndrome de Stevens-Johnson
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Predisposición Genética a la Enfermedad
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Estudios de Asociación Genética
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Antígenos HLA
Tipo de estudio:
Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Pharmacogenet Genomics
Asunto de la revista:
FARMACOLOGIA
/
GENETICA MEDICA
Año:
2015
Tipo del documento:
Article