Modeling the finger instability in an expanding cell monolayer.
Integr Biol (Camb)
; 7(10): 1218-27, 2015 Oct.
Article
en En
| MEDLINE
| ID: mdl-26099063
ABSTRACT
Collective motion occurs in many biological processes, such as wound healing, tumor invasion and embryogenesis. Experiments of cell monolayer migration have revealed the spontaneous formation of finger-like instabilities, with leader cells at their tips. We present a particle-based model for collective cell migration, based on several elements that have been found experimentally to influence cellular movement. Inside the bulk we include velocity alignment interactions between neighboring cells. At the border contour of the layer we introduce the following additional forces surface-elasticity restoring force, curvature-dependent positive feedback, and contractile acto-myosin cables. We find that the curvature-driven instability at the layer edge is necessary and sufficient for the formation of cellular fingers, which are in good agreement with experimental observations.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Movimiento Celular
/
Extensiones de la Superficie Celular
/
Modelos Biológicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Integr Biol (Camb)
Asunto de la revista:
BIOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Israel