Bioactive C21 Steroidal Glycosides from the Roots of Cynanchum otophyllum That Suppress the Seizure-like Locomotor Activity of Zebrafish Caused by Pentylenetetrazole.
J Nat Prod
; 78(7): 1548-55, 2015 Jul 24.
Article
en En
| MEDLINE
| ID: mdl-26135914
ABSTRACT
Six new C21 steroidal glycosides, cynotophyllosides A-F (1-6), together with 16 known compounds, were isolated from the roots of Cynanchum otophyllum. The structures of the new compounds were elucidated by spectroscopic analysis and chemical methods. The three major components, otophylloside F (15), otophylloside B (17), and rostratamine 3-O-ß-D-oleandropyranosyl-(1â4)-ß-D-cymaropyranosyl-(1â4)-ß-D-cymaropyranoside (18), suppressed the seizure-like locomotor activity caused by pentylenetetrazole in zebrafish. Preliminary structure-activity relation studies revealed that a pregnene skeleton with a C-12 ester group (ikemaoyl > cinnamoyl > hydroxy > p-hydroxybenzoyl) and a C-3 sugar chain consisting of three 2,6-dideoxysaccharide units is essential for this suppressive activity.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pentilenotetrazol
/
Pregnenos
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Convulsiones
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Medicamentos Herbarios Chinos
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Cynanchum
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Glicósidos
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Actividad Motora
Límite:
Animals
Idioma:
En
Revista:
J Nat Prod
Año:
2015
Tipo del documento:
Article