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Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys.
Barouch, Dan H; Alter, Galit; Broge, Thomas; Linde, Caitlyn; Ackerman, Margaret E; Brown, Eric P; Borducchi, Erica N; Smith, Kaitlin M; Nkolola, Joseph P; Liu, Jinyan; Shields, Jennifer; Parenteau, Lily; Whitney, James B; Abbink, Peter; Ng'ang'a, David M; Seaman, Michael S; Lavine, Christy L; Perry, James R; Li, Wenjun; Colantonio, Arnaud D; Lewis, Mark G; Chen, Bing; Wenschuh, Holger; Reimer, Ulf; Piatak, Michael; Lifson, Jeffrey D; Handley, Scott A; Virgin, Herbert W; Koutsoukos, Marguerite; Lorin, Clarisse; Voss, Gerald; Weijtens, Mo; Pau, Maria G; Schuitemaker, Hanneke.
Afiliación
  • Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA. dbarouch@bidmc.harvard.edu.
  • Alter G; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
  • Broge T; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
  • Linde C; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
  • Ackerman ME; Thayer School of Engineering at Dartmouth, Hanover, NH 03755, USA.
  • Brown EP; Thayer School of Engineering at Dartmouth, Hanover, NH 03755, USA.
  • Borducchi EN; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Smith KM; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Nkolola JP; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Liu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Shields J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Parenteau L; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Whitney JB; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Abbink P; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Ng'ang'a DM; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Lavine CL; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Perry JR; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Li W; University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Colantonio AD; New England Primate Research Center, Southborough, MA 01772, USA.
  • Lewis MG; Bioqual, Rockville, MD 20852, USA.
  • Chen B; Children's Hospital, Boston, MA 02115, USA.
  • Wenschuh H; JPT Peptide Technologies GmbH, 12489 Berlin, Germany.
  • Reimer U; JPT Peptide Technologies GmbH, 12489 Berlin, Germany.
  • Piatak M; AIDS and Cancer Virus Program, Leidos Biomedical Research, Frederick National Laboratory, Frederick, MD 21702, USA.
  • Lifson JD; AIDS and Cancer Virus Program, Leidos Biomedical Research, Frederick National Laboratory, Frederick, MD 21702, USA.
  • Handley SA; Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Virgin HW; Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Koutsoukos M; GSK Vaccines, 1330 Rixensart, Belgium.
  • Lorin C; GSK Vaccines, 1330 Rixensart, Belgium.
  • Voss G; GSK Vaccines, 1330 Rixensart, Belgium.
  • Weijtens M; Janssen Infectious Diseases and Vaccines (formerly Crucell), 2301 Leiden, Netherlands.
  • Pau MG; Janssen Infectious Diseases and Vaccines (formerly Crucell), 2301 Leiden, Netherlands.
  • Schuitemaker H; Janssen Infectious Diseases and Vaccines (formerly Crucell), 2301 Leiden, Netherlands.
Science ; 349(6245): 320-4, 2015 Jul 17.
Article en En | MEDLINE | ID: mdl-26138104
Preclinical studies of viral vector-based HIV-1 vaccine candidates have previously shown partial protection against neutralization-resistant virus challenges in rhesus monkeys. In this study, we evaluated the protective efficacy of adenovirus serotype 26 (Ad26) vector priming followed by purified envelope (Env) glycoprotein boosting. Rhesus monkeys primed with Ad26 vectors expressing SIVsmE543 Env, Gag, and Pol and boosted with AS01B-adjuvanted SIVmac32H Env gp140 demonstrated complete protection in 50% of vaccinated animals against a series of repeated, heterologous, intrarectal SIVmac251 challenges that infected all controls. Protective efficacy correlated with the functionality of Env-specific antibody responses. Comparable protection was also observed with a similar Ad/Env vaccine against repeated, heterologous, intrarectal SHIV-SF162P3 challenges. These data demonstrate robust protection by Ad/Env vaccines against acquisition of neutralization-resistant virus challenges in rhesus monkeys.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Productos del Gen env / Síndrome de Inmunodeficiencia Adquirida del Simio / VIH-1 / Vacunas contra el SIDA / Vacunas contra el SIDAS / Vacunas contra el Adenovirus Límite: Animals Idioma: En Revista: Science Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Productos del Gen env / Síndrome de Inmunodeficiencia Adquirida del Simio / VIH-1 / Vacunas contra el SIDA / Vacunas contra el SIDAS / Vacunas contra el Adenovirus Límite: Animals Idioma: En Revista: Science Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos