CCR5Δ32 mutation and HIV infection: basis for curative HIV therapy.
Curr Opin Virol
; 14: 24-9, 2015 Oct.
Article
en En
| MEDLINE
| ID: mdl-26143158
ABSTRACT
The C-C chemokine receptor 5 (CCR5) is expressed on potential human immunodeficiency virus (HIV) target cells and serves as the predominant co-receptor for viral entry during initial transmission and through the early stages of infection. A homozygous Δ32 mutation in the CCR5 gene prevents CCR5 cell surface expression and thus confers resistance to infection with CCR5-tropic HIV strains. Transplantation of hematopoietic stem cells from a CCR5Δ32/Δ32 donor was previously successful in eliminating HIV from the recipient's immune system, suggesting that targeted CCR5 disruption can lead to an HIV cure. Therefore, intense work is currently being carried out on CCR5 gene-editing tools to develop curative HIV therapy. Here, we review the natural function of CCR5, the progress made on CCR5 gene editing to date and discuss the current limitations.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
Problema de salud:
2_enfermedades_transmissibles
Asunto principal:
Terapia Genética
/
Infecciones por VIH
/
Receptores del VIH
/
Eliminación de Secuencia
/
Receptores CCR5
/
Trasplante de Células Madre
Límite:
Humans
Idioma:
En
Revista:
Curr Opin Virol
Año:
2015
Tipo del documento:
Article