Clinical significance of plasma lysophosphatidic acid levels in the differential diagnosis of ovarian cancer.
J Cancer Res Ther
; 11(2): 375-80, 2015.
Article
en En
| MEDLINE
| ID: mdl-26148603
ABSTRACT
OBJECTIVE:
To investigate the value of lysophosphatidic acid (LPA) in the diagnosis of ovarian cancer. MATERIALS ANDMETHODS:
We first performed a hospital-based, case-control study involving 123 ovarian cancer patients and 101 benign ovarian tumor patients, and then conducted a meta-analysis with 19 case-control studies to assess the correlation between ovarian cancer and plasma LPA levels.RESULTS:
The case-control study results demonstrated that ovarian cancer patients have increased LPA and cancer antigen (CA)-125 levels compared to patients with benign ovarian tumor (LPA Ovarian cancer vs benign ovarian tumor 5.28 ± 1.52 vs 1.82 ± 0.77 µmol/L; CA-125 Ovarian cancer vs benign ovarian tumor 87.17 ± 45.81 vs. 14.03 ± 10.14 U/mL), which showed statistically significant differences (both P < 0.05). LPA with advanced sensitivity, specificity, positive predictive value, negative predictive value, and accuracy rate of diagnosis excelled CA-125 in the diagnosis of ovarian cancer (both P < 0.05). The areas under the receiver operating characteristic (ROC) curve in the diagnosis of ovarian cancer (LPA 0.983; CA-125 0.910) were statistically significant compared with the reference (both P < 0.001) and the difference of the areas of ROC curve between LPA and CA-125 in the diagnosis of ovarian cancer showed statistically significant difference (P < 0.05). The meta-analysis results suggested that plasma LPA levels were higher in ovarian cancer tissues than in benign tissues (standardized mean difference (SMD) =2.36, 95% confidence interval (CI) 1.61-3.11, P < 0.001) and normal tissues (SMD = 2.32, 95% CI 1.77-2.87, P < 0.001).CONCLUSION:
LPA shows greater value in the diagnosis of ovarian cancer compared to CA-125 and may be employed as a biological index to diagnose ovarian cancer.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
/
Lisofosfolípidos
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Adult
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Aged
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Female
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Humans
/
Middle aged
Idioma:
En
Revista:
J Cancer Res Ther
Asunto de la revista:
NEOPLASIAS
/
TERAPEUTICA
Año:
2015
Tipo del documento:
Article
País de afiliación:
China