Role of Autophagy in the Maintenance of Intestinal Homeostasis.
Gastroenterology
; 149(3): 553-62, 2015 Sep.
Article
en En
| MEDLINE
| ID: mdl-26170139
ABSTRACT
Genome-wide association studies of inflammatory bowel disease have identified several risk loci in genes that regulate autophagy, and studies have provided insight into the functional effects of these polymorphisms. We review the mechanisms by which autophagy contributes to intestinal homeostasis, focusing on its cell type-specific roles in regulating gut ecology, restricting pathogenic bacteria, and controlling inflammation. Based on this information, we are beginning to understand how alterations in autophagy can contribute to intestinal inflammation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Autofagia
/
Enfermedades Inflamatorias del Intestino
/
Intestinos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Gastroenterology
Año:
2015
Tipo del documento:
Article