Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread.

Giannoni, Elisa; Taddei, Maria Letizia; Morandi, Andrea; Comito, Giuseppina; Calvani, Maura; Bianchini, Francesca; Richichi, Barbara; Raugei, Giovanni; Wong, Nicholas; Tang, Damu; Chiarugi, Paola

Giannoni, Elisa; Taddei, Maria Letizia; Morandi, Andrea; Comito, Giuseppina; Calvani, Maura; Bianchini, Francesca; Richichi, Barbara; Raugei, Giovanni; Wong, Nicholas; Tang, Damu; Chiarugi, Paola.

Afiliación

Giannoni E; Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134, Florence, Italy.
Taddei ML; Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134, Florence, Italy.
Morandi A; Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134, Florence, Italy.
Comito G; Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134, Florence, Italy.
Calvani M; Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134, Florence, Italy.
Bianchini F; Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134, Florence, Italy.
Richichi B; Department of Chemistry, University of Florence, 50019, Sesto Fiorentino, Italy.
Raugei G; Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134, Florence, Italy.
Wong N; Division of Nephrology, Department of Medicine, McMaster University, L8N4A6, Hamilton, Ontario, Canada.
Tang D; Division of Nephrology, Department of Medicine, McMaster University, L8N4A6, Hamilton, Ontario, Canada.
Chiarugi P; Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134, Florence, Italy.

Oncotarget ; 6(27): 24061-74, 2015 Sep 15.

Article en En | MEDLINE | ID: mdl-26183399

Asunto(s)

Transporte Activo de Núcleo Celular; Proteínas Portadoras/metabolismo; Proteínas de la Membrana/metabolismo; Neoplasias de la Próstata/patología; Piruvato Quinasa/metabolismo; Hormonas Tiroideas/metabolismo; Animales; Sitios de Unión; Carcinoma/metabolismo; Carcinoma/patología; Línea Celular Tumoral; Núcleo Celular/metabolismo; Estudios de Cohortes; Cisteína/química; Fibroblastos/metabolismo; Glucosa/química; Humanos; Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo; Inmunohistoquímica; Ácido Láctico/química; Masculino; Metformina/química; Ratones; Ratones SCID; MicroARNs/metabolismo; Metástasis de la Neoplasia; Oxidación-Reducción; Fosforilación Oxidativa; Oxígeno/química; Neoplasias de la Próstata/metabolismo; Proteínas Supresoras de Tumor/metabolismo; Proteínas de Unión a Hormona Tiroide

Palabras clave

cancer associated fibroblasts; epithelial-mesenchymal transition; hypoxia inducible factor-1α; prostate cancer; pyruvate kinase M2

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Piruvato Quinasa / Hormonas Tiroideas / Proteínas Portadoras / Transporte Activo de Núcleo Celular / Proteínas de la Membrana Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Animals / Humans / Male Idioma: En Revista: Oncotarget Año: 2015 Tipo del documento: Article País de afiliación: Italia

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