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Viral exposures and MS outcome in a prospective cohort of children with acquired demyelination.
Makhani, Naila; Banwell, Brenda; Tellier, Raymond; Yea, Carmen; McGovern, Suzanne; O'Mahony, Julia; Ahorro, Jean M; Arnold, Douglas; Sadovnick, A Dessa; Marrie, Ruth A; Bar-Or, Amit.
Afiliación
  • Makhani N; Departments of Pediatrics and Neurology, Yale University School of Medicine, USA naila.makhani@yale.edu.
  • Banwell B; Department of Pediatrics, The Children's Hospital of Philadelphia and University of Pennsylvania, USA.
  • Tellier R; Departments of Microbiology, Immunology and Infectious Diseases, University of Calgary, Canada.
  • Yea C; The Hospital for Sick Children, University of Toronto, Canada.
  • McGovern S; The Hospital for Sick Children, University of Toronto, Canada.
  • O'Mahony J; Institute of Health Policy, Management, and Evaluation, University of Toronto and The Hospital for Sick Children, Toronto, Canada.
  • Ahorro JM; Calamba Doctors' Hospital, Philippines.
  • Arnold D; Montreal Neurological Institute and McGill University, Canada.
  • Sadovnick AD; Division of Neurology and Department of Medical Genetics, University of British Columbia, Canada.
  • Marrie RA; Departments of Internal Medicine and Community Health Sciences, University of Manitoba, Canada.
  • Bar-Or A; Montreal Neurological Institute and McGill University, Canada.
Mult Scler ; 22(3): 385-8, 2016 Mar.
Article en En | MEDLINE | ID: mdl-26199356
ABSTRACT
Epstein-Barr virus (EBV) infection is associated with increased multiple sclerosis (MS) risk. Recently, cytomegalovirus (CMV) infection has been proposed as a protective factor against MS development. We determined EBV, herpes simplex virus, varicella-zoster virus and CMV seroprevalence in 247 prospectively followed children with acquired demyelinating syndromes (ADS). Remote EBV infection was more common in children with MS than those with monophasic ADS while CMV infection was more common in children with monophasic ADS. Children displaying evidence of remote EBV without CMV infection were at highest risk of subsequent MS diagnosis. Viral infection repertoire detected at ADS provides important prognostic information.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Desmielinizantes / Infecciones por Citomegalovirus / Infecciones por Virus de Epstein-Barr / Esclerosis Múltiple Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Male Idioma: En Revista: Mult Scler Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Desmielinizantes / Infecciones por Citomegalovirus / Infecciones por Virus de Epstein-Barr / Esclerosis Múltiple Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Male Idioma: En Revista: Mult Scler Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos