Efficiency of photodynamic therapy on WM35 melanoma with synthetic porphyrins: Role of chemical structure, intracellular targeting and antioxidant defense.

Baldea, Ioana; Olteanu, Diana Elena; Bolfa, Pompei; Ion, Rodica Mariana; Decea, Nicoleta; Cenariu, Mihai; Banciu, Manuela; Sesarman, Alina Viorica; Filip, Adriana Gabriela

Baldea, Ioana; Olteanu, Diana Elena; Bolfa, Pompei; Ion, Rodica Mariana; Decea, Nicoleta; Cenariu, Mihai; Banciu, Manuela; Sesarman, Alina Viorica; Filip, Adriana Gabriela.

Afiliación

Baldea I; University of Medicine and Pharmacy, Department of Physiology, Clinicilor 1, Cluj-Napoca, Romania. Electronic address: baldeai@yahoo.com.
Olteanu DE; University of Medicine and Pharmacy, Department of Physiology, Clinicilor 1, Cluj-Napoca, Romania. Electronic address: ariana_di@yahoo.com.
Bolfa P; University of Agricultural Sciences and Veterinary Medicine, Department of Pathology, Calea Manastur 3-5, 400372 Cluj-Napoca, Romania; Ross University School of Veterinary Medicine, Department of Biomedical Sciences, PO Box 334, Basseterre, Saint Kitts and Nevis. Electronic address: pompei.bolfa@usa
Ion RM; National Institute for Research & Development in Chemistry and Petrochemistry - ICECHIM, Nanomedicine Research Group, 202 Splaiul Independentei, Sector 6, Bucharest, Romania. Electronic address: rodicaion2000@yahoo.co.uk.
Decea N; University of Medicine and Pharmacy, Department of Physiology, Clinicilor 1, Cluj-Napoca, Romania. Electronic address: nicoleta_decea@yahoo.com.
Cenariu M; University of Agricultural Sciences and Veterinary Medicine, Department of Biochemistry, Calea Manastur 3-5, 400372 Cluj-Napoca, Romania. Electronic address: mihai.cenariu@usamvcluj.ro.
Banciu M; Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, Clinicilor Street 5-7, 400006 Cluj-Napoca, Romania. Electronic address: manuela.banciu@ubbcluj.ro.
Sesarman AV; Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, Clinicilor Street 5-7, 400006 Cluj-Napoca, Romania. Electronic address: alina.sesarman@hasdeu.ubbcluj.ro.
Filip AG; University of Medicine and Pharmacy, Department of Physiology, Clinicilor 1, Cluj-Napoca, Romania. Electronic address: adrianafilip33@yahoo.com.

J Photochem Photobiol B ; 151: 142-52, 2015 Oct.

Article en En | MEDLINE | ID: mdl-26257158

Asunto(s)

Melanoma/tratamiento farmacológico; Fotoquimioterapia/métodos; Fármacos Fotosensibilizantes/farmacología; Porfirinas/química; Porfirinas/farmacología; Antineoplásicos/química; Antineoplásicos/farmacología; Antioxidantes/metabolismo; Línea Celular Tumoral; Supervivencia Celular/efectos de los fármacos; Citometría de Flujo; Humanos; Peroxidación de Lípido/efectos de los fármacos; Melanoma/metabolismo; Melanoma/patología; FN-kappa B/metabolismo; Estrés Oxidativo/efectos de los fármacos; Fármacos Fotosensibilizantes/química; Relación Estructura-Actividad; Superóxido Dismutasa/metabolismo; Factor de Necrosis Tumoral alfa/metabolismo

Palabras clave

Apoptosis; Melanogenesis; Melanoma; Meso-5,10,15,20-tetrakis (4-hydroxyphenyl) porphyrin; Meso-5-(4-hydroxyphenyl)-10,15,20-tris (4-methoxyphenyl) porphyrin; Oxidative stress; Photodynamic therapy

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Porfirinas / Fármacos Fotosensibilizantes / Melanoma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Photochem Photobiol B Asunto de la revista: BIOLOGIA Año: 2015 Tipo del documento: Article

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