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Pyrimidine sulfonylacetanilides with improved potency against key mutant viruses of HIV-1 by specific targeting of a highly conserved residue.
Wan, Zheng-Yong; Yao, Jin; Mao, Tian-Qi; Wang, Xin-Long; Wang, Hai-Feng; Chen, Wen-Xue; Yin, Hong; Chen, Fen-Er; De Clercq, Erik; Daelemans, Dirk; Pannecouque, Christophe.
Afiliación
  • Wan ZY; Department of Chemistry, Fudan University, Shanghai 200433, PR China.
  • Yao J; Department of Chemistry, Fudan University, Shanghai 200433, PR China.
  • Mao TQ; Department of Chemistry, Fudan University, Shanghai 200433, PR China; Institute of Biomedical Science, Fudan University, Shanghai 200433, PR China.
  • Wang XL; Department of Chemistry, Fudan University, Shanghai 200433, PR China.
  • Wang HF; Department of Chemistry, Fudan University, Shanghai 200433, PR China.
  • Chen WX; Department of Chemistry, Fudan University, Shanghai 200433, PR China.
  • Yin H; Department of Chemistry, Fudan University, Shanghai 200433, PR China. Electronic address: ahredy@126.com.
  • Chen FE; Department of Chemistry, Fudan University, Shanghai 200433, PR China; Institute of Biomedical Science, Fudan University, Shanghai 200433, PR China. Electronic address: rfchen@fudan.edu.cn.
  • De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
  • Daelemans D; Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
  • Pannecouque C; Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Eur J Med Chem ; 102: 215-22, 2015 Sep 18.
Article en En | MEDLINE | ID: mdl-26276435
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / VIH-1 / Secuencia Conservada / Inhibidores de la Transcriptasa Inversa / Fármacos Anti-VIH / Acetanilidas / Mutación Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2015 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / VIH-1 / Secuencia Conservada / Inhibidores de la Transcriptasa Inversa / Fármacos Anti-VIH / Acetanilidas / Mutación Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2015 Tipo del documento: Article