Corneal Epithelial Wound Healing.
Prog Mol Biol Transl Sci
; 134: 61-71, 2015.
Article
en En
| MEDLINE
| ID: mdl-26310149
ABSTRACT
The cornea is important for a clear vision by refracting light onto the lens, which in turn focusing on the retina. To maintain a smooth optical surface, corneal epithelium has to continuously renew itself to function as a barrier so that it protects the eye from various environmental insults. The adult corneal epithelium is maintained homeostatically by an integrated process of cell proliferation, migration, differentiation, stratification, and desquamation/apoptosis. Impairment of this process results in persistent corneal defect, leading to the blindness. Researches throughout the years revealed that appropriate integration and coordination of cell signaling events are responsible for corneal epithelial renewal and wound healing. In this chapter, we will review works done on cell culture, animal models, and human trials to focus on the signaling network during corneal wound healing process which will have potential for the discovery of novel drug to improve corneal wound healing.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cicatrización de Heridas
/
Epitelio Corneal
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Prog Mol Biol Transl Sci
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2015
Tipo del documento:
Article