Current status of pig heart xenotransplantation.
Int J Surg
; 23(Pt B): 234-239, 2015 Nov.
Article
en En
| MEDLINE
| ID: mdl-26318967
ABSTRACT
Significant progress in understanding and overcoming cardiac xenograft rejection using a clinically relevant large animal pig-to-baboon model has accelerated in recent years. This advancement is based on improved immune suppression, which attained more effective regulation of B lymphocytes and possibly newer donor genetics. These improvements have enhanced heterotopic cardiac xenograft survival from a few weeks to over 2 years, achieved intrathoracic heterotopic cardiac xenograft survival of 50 days and orthotopic survival of 57 days. This encouraging progress has rekindled interest in xenotransplantation research and refocused efforts on preclinical orthotopic cardiac xenotransplantation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Papio
/
Porcinos
/
Trasplante Heterólogo
/
Trasplante de Corazón
/
Supervivencia de Injerto
Límite:
Animals
Idioma:
En
Revista:
Int J Surg
Año:
2015
Tipo del documento:
Article