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Effect of Saccharomyces cerevisiae strain UFMG A-905 in experimental model of inflammatory bowel disease.
Tiago, F C P; Porto, B A A; Ribeiro, N S; Moreira, L M C; Arantes, R M E; Vieira, A T; Teixeira, M M; Generoso, S V; Nascimento, V N; Martins, F S; Nicoli, J R.
Afiliación
  • Tiago FC; 1 Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
  • Porto BA; 1 Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
  • Ribeiro NS; 1 Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
  • Moreira LM; 1 Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
  • Arantes RM; 2 Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
  • Vieira AT; 3 Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
  • Teixeira MM; 3 Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
  • Generoso SV; 4 School of Pharmacy, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
  • Nascimento VN; 4 School of Pharmacy, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
  • Martins FS; 1 Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
  • Nicoli JR; 1 Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Presidente Antônio Carlos 6627, C.P. 486, Pampulha - Campus UFMG, 31270-901, Belo Horizonte, MG, Brazil.
Benef Microbes ; 6(6): 807-15, 2015.
Article en En | MEDLINE | ID: mdl-26322540
ABSTRACT
In the present study, the protective potential of Saccharomyces cerevisiae strain UFMG A-905 was evaluated in a murine model of acute ulcerative colitis (UC). Six groups of Balb/c mice were used not treated with yeast and not challenged with dextran sulphate sodium (DSS) (control); treated with S. cerevisiae UFMG A-905 (905); treated with the non-probiotic S. cerevisiae W303 (W303); challenged with DSS (DSS); treated with S. cerevisiae UFMG A-905 and challenged with DSS (905 + DSS); and treated with S. cerevisiae W303 and challenged with DSS (W303 + DSS). Seven days after induction of UC, mice were euthanised to remove colon for enzymatic, immunological, and histopathological analysis. In vivo intestinal permeability was also evaluated. An improvement of clinical manifestations of experimental UC was observed only in mice of the 905 + DSS group when compared to animals from DSS and W303 + DSS groups. This observation was confirmed by histological and morphometrical data and determination of myeloperoxidase and eosinophil peroxidase activities, intestinal permeability and some pro-inflammatory cytokines. S. cerevisiae UFMG A-905 showed to be a potential alternative treatment for UC when used in an experimental animal model of the disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saccharomyces cerevisiae / Enfermedades Inflamatorias del Intestino / Colon / Probióticos Límite: Animals Idioma: En Revista: Benef Microbes Año: 2015 Tipo del documento: Article País de afiliación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saccharomyces cerevisiae / Enfermedades Inflamatorias del Intestino / Colon / Probióticos Límite: Animals Idioma: En Revista: Benef Microbes Año: 2015 Tipo del documento: Article País de afiliación: Brasil