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Antibody-Dependent Cellular Inhibition Is Associated With Reduced Risk Against Febrile Malaria in a Longitudinal Cohort Study Involving Ghanaian Children.
Tiendrebeogo, Regis W; Adu, Bright; Singh, Susheel K; Dziegiel, Morten H; Nébié, Issa; Sirima, Sodiomon B; Christiansen, Michael; Dodoo, Daniel; Theisen, Michael.
Afiliación
  • Tiendrebeogo RW; Department of Clinical Biochemistry, Immunology and Genetics , Statens Serum Institut , Copenhagen ; Centre for Medical Parasitology at Department of International Health, Immunology, Microbiology, and Department of Infectious Diseases , Rigshospitalet, University of Copenhagen.
  • Adu B; Department of Clinical Biochemistry, Immunology and Genetics , Statens Serum Institut , Copenhagen ; Centre for Medical Parasitology at Department of International Health, Immunology, Microbiology, and Department of Infectious Diseases , Rigshospitalet, University of Copenhagen.
  • Singh SK; Department of Clinical Biochemistry, Immunology and Genetics , Statens Serum Institut , Copenhagen ; Centre for Medical Parasitology at Department of International Health, Immunology, Microbiology, and Department of Infectious Diseases , Rigshospitalet, University of Copenhagen.
  • Dziegiel MH; Blood Bank KI 2034, Copenhagen University Hospital , Denmark.
  • Nébié I; Centre National de Recherche et de Formation sur le Paludisme , Ouagadougou , Burkina Faso.
  • Sirima SB; Centre National de Recherche et de Formation sur le Paludisme , Ouagadougou , Burkina Faso.
  • Christiansen M; Department of Clinical Biochemistry, Immunology and Genetics , Statens Serum Institut , Copenhagen.
  • Dodoo D; Noguchi Memorial Institute for Medical Research , University of Ghana , Legon.
  • Theisen M; Department of Clinical Biochemistry, Immunology and Genetics , Statens Serum Institut , Copenhagen ; Centre for Medical Parasitology at Department of International Health, Immunology, Microbiology, and Department of Infectious Diseases , Rigshospitalet, University of Copenhagen.
Open Forum Infect Dis ; 2(2): ofv044, 2015 Apr.
Article en En | MEDLINE | ID: mdl-26380342
ABSTRACT
The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly associated with reduced risk against malaria. Findings here suggest a potential usefulness of the ADCI assay as a correlate of protection to guide malaria vaccine studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 3_ND Problema de salud: 2_enfermedades_transmissibles / 3_malaria / 3_neglected_diseases Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: Open Forum Infect Dis Año: 2015 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 3_ND Problema de salud: 2_enfermedades_transmissibles / 3_malaria / 3_neglected_diseases Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: Open Forum Infect Dis Año: 2015 Tipo del documento: Article