Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism.

Gooding, Jessica R; Jensen, Mette V; Dai, Xiaoqing; Wenner, Brett R; Lu, Danhong; Arumugam, Ramamani; Ferdaoussi, Mourad; MacDonald, Patrick E; Newgard, Christopher B

Gooding, Jessica R; Jensen, Mette V; Dai, Xiaoqing; Wenner, Brett R; Lu, Danhong; Arumugam, Ramamani; Ferdaoussi, Mourad; MacDonald, Patrick E; Newgard, Christopher B.

Afiliación

Gooding JR; Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center, Durham, NC 27701, USA.
Jensen MV; Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center, Durham, NC 27701, USA.
Dai X; Alberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Wenner BR; Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center, Durham, NC 27701, USA.
Lu D; Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center, Durham, NC 27701, USA.
Arumugam R; Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center, Durham, NC 27701, USA.
Ferdaoussi M; Alberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, AB T6G 2E1, Canada.
MacDonald PE; Alberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, AB T6G 2E1, Canada. Electronic address: pmacdonald@ualberta.ca.
Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center, Durham, NC 27701, USA. Electronic address: chris.newgard@duke.edu.

Cell Rep ; 13(1): 157-167, 2015 Oct 06.

Article en En | MEDLINE | ID: mdl-26411681

Asunto(s)

Adenosina Monofosfato/análogos & derivados; Diabetes Mellitus Tipo 2/metabolismo; Glucosa/farmacología; Células Secretoras de Insulina/efectos de los fármacos; Adenosina Monofosfato/metabolismo; Adenosina Monofosfato/farmacología; Adenilosuccinato Liasa/antagonistas & inhibidores; Adenilosuccinato Liasa/genética; Adenilosuccinato Liasa/metabolismo; Adenilosuccinato Sintasa/antagonistas & inhibidores; Adenilosuccinato Sintasa/genética; Adenilosuccinato Sintasa/metabolismo; Animales; Línea Celular Tumoral; Cisteína Endopeptidasas; Diabetes Mellitus Tipo 2/genética; Diabetes Mellitus Tipo 2/patología; Endopeptidasas/genética; Endopeptidasas/metabolismo; Inhibidores Enzimáticos/farmacología; Exocitosis/efectos de los fármacos; Regulación de la Expresión Génica; Glucosa/metabolismo; Guanina/farmacología; Humanos; Inosina Monofosfato/metabolismo; Insulina/biosíntesis; Insulina/metabolismo; Secreción de Insulina; Células Secretoras de Insulina/metabolismo; Células Secretoras de Insulina/patología; Metaboloma/genética; Ácido Micofenólico/farmacología; Técnicas de Placa-Clamp; Cultivo Primario de Células; Ratas; Ratas Sprague-Dawley; Transducción de Señal

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenosina Monofosfato / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina / Glucosa Idioma: En Revista: Cell Rep Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

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