Diversity-oriented heterocyclic synthesis using divergent reactivity of N-substituted iso(thio)cyanates.
Chem Commun (Camb)
; 51(91): 16405-8, 2015 Nov 25.
Article
en En
| MEDLINE
| ID: mdl-26412362
ABSTRACT
Carbon-substituted isocyanates and isothiocyanates are common building blocks in organic synthesis. In contrast, synthetic uses of N-substituted isocyanates and isothiocyanates are severely underdeveloped few have been reported and their reactivity had not been compared. Herein, we compare the reactivity of blocked (masked) N-isocyanate and N-isothiocyanate precursors in cascade reactions. Divergent reactivity is observed with secondary propargylic and allylic systems, leading to new syntheses of imidazolones, thiazolidines, and a tool to form complex azomethine imines.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Isotiocianatos
/
Isocianatos
/
Técnicas de Química Sintética
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Canadá