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Enantioselective Synthesis of Hemiaminals via Pd-Catalyzed C-N Coupling with Chiral Bisphosphine Mono-oxides.
Li, Hongming; Belyk, Kevin M; Yin, Jingjun; Chen, Qinghao; Hyde, Alan; Ji, Yining; Oliver, Steven; Tudge, Matthew T; Campeau, Louis-Charles; Campos, Kevin R.
Afiliación
  • Li H; Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
  • Belyk KM; Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
  • Yin J; Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
  • Chen Q; Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
  • Hyde A; Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
  • Ji Y; Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
  • Oliver S; Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
  • Tudge MT; Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
  • Campeau LC; Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
  • Campos KR; Department of Process Chemistry, Merck & Co. Inc. , Rahway, New Jersey 07065, United States.
J Am Chem Soc ; 137(43): 13728-31, 2015 Nov 04.
Article en En | MEDLINE | ID: mdl-26414910
A novel approach to hemiaminal synthesis via palladium-catalyzed C-N coupling with chiral bisphosphine mono-oxides is described. This efficient new method exhibits a broad scope, provides a highly efficient synthesis of HCV drug candidate elbasvir, and has been applied to the synthesis of chiral N,N-acetals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Am Chem Soc Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Am Chem Soc Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos