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A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects.
Charette, Jeremy R; Samuels, Ivy S; Yu, Minzhong; Stone, Lisa; Hicks, Wanda; Shi, Lan Ying; Krebs, Mark P; Naggert, Jürgen K; Nishina, Patsy M; Peachey, Neal S.
Afiliación
  • Charette JR; The Jackson Laboratory, 04609, Bar Harbor, ME, USA. Jeremy.Charette@jax.org.
  • Samuels IS; Louis Stokes Cleveland VA Medical Center, 44106, Cleveland, OH, USA. Ivy.Samuels@va.gov.
  • Yu M; Cole Eye Institute, Cleveland Clinic, 44195, Cleveland, OH, USA. YUM@ccf.org.
  • Stone L; The Jackson Laboratory, 04609, Bar Harbor, ME, USA. Lisa.Stone@jax.org.
  • Hicks W; The Jackson Laboratory, 04609, Bar Harbor, ME, USA. Wanda.jordan@jax.org.
  • Shi LY; The Jackson Laboratory, 04609, Bar Harbor, ME, USA. lanying_shi1234@163.com.
  • Krebs MP; The Jackson Laboratory, 04609, Bar Harbor, ME, USA. Mark.Krebs@jax.org.
  • Naggert JK; The Jackson Laboratory, 04609, Bar Harbor, ME, USA. Juergen.Naggert@jax.org.
  • Nishina PM; The Jackson Laboratory, 04609, Bar Harbor, ME, USA. Nishina@jax.org.
  • Peachey NS; Louis Stokes Cleveland VA Medical Center, 44106, Cleveland, OH, USA. peachen@ccf.org.
Adv Exp Med Biol ; 854: 177-83, 2016.
Article en En | MEDLINE | ID: mdl-26427409
ABSTRACT
Mouse models provide important resources for many areas of vision research, pertaining to retinal development, retinal function and retinal disease. The Translational Vision Research Models (TVRM) program uses chemical mutagenesis to generate new mouse models for vision research. In this chapter, we report the identification of mouse models for Grm1, Grk1 and Lrit3. Each of these is characterized by a primary defect in the electroretinogram. All are available without restriction to the research community.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 Problema de salud: 1_geracao_evidencia_conhecimento Asunto principal: Retina / Enfermedades de la Retina / Predisposición Genética a la Enfermedad / Mutación Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Adv Exp Med Biol Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 Problema de salud: 1_geracao_evidencia_conhecimento Asunto principal: Retina / Enfermedades de la Retina / Predisposición Genética a la Enfermedad / Mutación Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Adv Exp Med Biol Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos