Hit and lead criteria in drug discovery for infectious diseases of the developing world.
Nat Rev Drug Discov
; 14(11): 751-8, 2015 Nov.
Article
en En
| MEDLINE
| ID: mdl-26435527
ABSTRACT
Reducing the burden of infectious diseases that affect people in the developing world requires sustained collaborative drug discovery efforts. The quality of the chemical starting points for such projects is a key factor in improving the likelihood of clinical success, and so it is important to set clear go/no-go criteria for the progression of hit and lead compounds. With this in mind, the Japanese Global Health Innovative Technology (GHIT) Fund convened with experts from the Medicines for Malaria Venture, the Drugs for Neglected Diseases initiative and the TB Alliance, together with representatives from the Bill &Melinda Gates Foundation, to set disease-specific criteria for hits and leads for malaria, tuberculosis, visceral leishmaniasis and Chagas disease. Here, we present the agreed criteria and discuss the underlying rationale.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
/
3_ND
Problema de salud:
2_cobertura_universal
/
2_enfermedades_transmissibles
/
3_chagas_disease
/
3_malaria
/
3_neglected_diseases
/
3_tuberculosis
Asunto principal:
Tuberculosis
/
Países en Desarrollo
/
Descubrimiento de Drogas
/
Enfermedades Desatendidas
/
Fundaciones
/
Malaria
Aspecto:
Determinantes_sociais_saude
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Drug Discov
Asunto de la revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
2015
Tipo del documento:
Article
País de afiliación:
Japón