New ribosomes for new memories?
Commun Integr Biol
; 8(2): e1017163, 2015.
Article
en En
| MEDLINE
| ID: mdl-26479998
ABSTRACT
Widely thought to be a housekeeping process, the regulation and synthesis of rRNA emerges as a potentially central mechanism for the maintenance of synaptic plasticity and memory. We have recently shown that an essential component of late-phase synaptic plasticity is rRNA biosynthesis - the rate-limiting step in the production of new ribosomes. We hypothesize that a particular population of ribosomes is generated upon learning-associated neural activity to alter the rate of synthesis of plasticity factors at tagged synapses that will support the maintenance of synaptic plasticity and memory.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Commun Integr Biol
Año:
2015
Tipo del documento:
Article