Near-IR mediated intracellular uncaging of NO from cell targeted hollow gold nanoparticles.
Chem Commun (Camb)
; 51(100): 17692-5, 2015 Dec 28.
Article
en En
| MEDLINE
| ID: mdl-26486468
ABSTRACT
We demonstrate modulation of nitric oxide release in solution and in human prostate cancer cells from a thiol functionalized cupferron (TCF) absorbed on hollow gold nanoshells (HGNs) using near-infrared (NIR) light. NO release from the TCF-HGN conjugates occurs through localized surface heating due to NIR excitation of the surface plasmon. Specific HGN targeting is achieved through cell surface directed peptides, and excitation with tissue penetrating NIR light provides unprecedented spatio-temporal control of NO delivery to biological targets.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Donantes de Óxido Nítrico
/
Nanocáscaras
/
Oro
/
Óxido Nítrico
Límite:
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2015
Tipo del documento:
Article