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Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders.
Hobson, Adrian D; Harris, Christopher M; van der Kam, Elizabeth L; Turner, Sean C; Abibi, Ayome; Aguirre, Ana L; Bousquet, Peter; Kebede, Tegest; Konopacki, Donald B; Gintant, Gary; Kim, Youngjae; Larson, Kelly; Maull, John W; Moore, Nigel S; Shi, Dan; Shrestha, Anurupa; Tang, Xiubo; Zhang, Peng; Sarris, Kathy K.
Afiliación
  • Hobson AD; AbbVie Bioresearch Center , 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Harris CM; AbbVie Bioresearch Center , 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • van der Kam EL; AbbVie Deutschland GmbH & Co KG , Knollstrasse 50, 67061 Ludwigshafen, Germany.
  • Turner SC; AbbVie Deutschland GmbH & Co KG , Knollstrasse 50, 67061 Ludwigshafen, Germany.
  • Abibi A; AbbVie Bioresearch Center , 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Aguirre AL; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Bousquet P; AbbVie Bioresearch Center , 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Kebede T; AbbVie Bioresearch Center , 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Konopacki DB; AbbVie Bioresearch Center , 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Gintant G; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Kim Y; AbbVie Bioresearch Center , 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Larson K; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Maull JW; AbbVie Bioresearch Center , 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Moore NS; AbbVie Bioresearch Center , 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Shi D; AbbVie Bioresearch Center , 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Shrestha A; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Tang X; Shanghai ChemPartner Co. Ltd. , Building 10, 998 Halei Road, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203, China.
  • Zhang P; Shanghai ChemPartner Co. Ltd. , Building 10, 998 Halei Road, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203, China.
  • Sarris KK; AbbVie, Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
J Med Chem ; 58(23): 9154-70, 2015 Dec 10.
Article en En | MEDLINE | ID: mdl-26509640
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Azetidinocarboxílico / Derivados del Benceno / Enfermedades Neurodegenerativas / Receptores de Lisoesfingolípidos Límite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Azetidinocarboxílico / Derivados del Benceno / Enfermedades Neurodegenerativas / Receptores de Lisoesfingolípidos Límite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos