[A Case of Severe Bradycardia Induced by Combination Chemotherapy with Cisplatin and 5-Fluorouracil].
Gan To Kagaku Ryoho
; 42(11): 1415-8, 2015 Nov.
Article
en Ja
| MEDLINE
| ID: mdl-26602402
ABSTRACT
A 78-year-old man with Stage III esophageal cancer was referred to our hospital. Combination chemotherapy with cisplatin (CDDP) and 5-fluorouracil (5-FU) was initiated. The patient experienced bradycardia episodes after starting the cisplatin infusion on day 1; he was otherwise asymptomatic. Therefore, combination chemotherapy was continued. However, on day 4, his heart rate dropped to 22 beats/min, with no other symptoms; however, treatment was stopped. After treatment was stopped, the patient's heart rate improved gradually and returned to normal in a few days. Combination chemotherapy with CDDP and 5-FU is a useful treatment for esophageal cancer, but it may induce severe bradycardia. Therefore, we must perform infusion therapy with caution.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bradicardia
/
Neoplasias Esofágicas
/
Protocolos de Quimioterapia Combinada Antineoplásica
Límite:
Aged
/
Humans
/
Male
Idioma:
Ja
Revista:
Gan To Kagaku Ryoho
Año:
2015
Tipo del documento:
Article