Controlling Cerebellar Output to Treat Refractory Epilepsy.
Trends Neurosci
; 38(12): 787-799, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-26602765
ABSTRACT
Generalized epilepsy is characterized by recurrent seizures caused by oscillatory neuronal firing throughout thalamocortical networks. Current therapeutic approaches often intervene at the level of the thalamus or cerebral cortex to ameliorate seizures. We review here the therapeutic potential of cerebellar stimulation. The cerebellum forms a prominent ascending input to the thalamus and, whereas stimulation of the foliated cerebellar cortex exerts inconsistent results, stimulation of the centrally located cerebellar nuclei (CN) reliably stops generalized seizures in experimental models. Stimulation of this area indicates that the period of stimulation with respect to the phase of the oscillations in thalamocortical networks can optimize its effect, opening up the possibility of developing on-demand deep brain stimulation (DBS) treatments.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
Problema de salud:
1_doencas_nao_transmissiveis
Asunto principal:
Cerebelo
/
Estimulación Encefálica Profunda
/
Epilepsia Refractaria
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Neurosci
Año:
2015
Tipo del documento:
Article
País de afiliación:
Países Bajos