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Vesicovascular reflexes in the spontaneously hypertensive rat.
Kawamoto, Bunya; Shimizu, Shogo; Shimizu, Takahiro; Higashi, Youichirou; Hikita, Katsuya; Muraoka, Kuniyasu; Honda, Masashi; Sejima, Takehiro; Takenaka, Atsushi; Saito, Motoaki.
Afiliación
  • Kawamoto B; Division of Urology, Department of Surgery, Tottori University Faculty of Medicine, Yonago, Japan.
  • Shimizu S; Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Japan.
  • Shimizu T; Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Japan.
  • Higashi Y; Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Japan.
  • Hikita K; Division of Urology, Department of Surgery, Tottori University Faculty of Medicine, Yonago, Japan.
  • Muraoka K; Division of Urology, Department of Surgery, Tottori University Faculty of Medicine, Yonago, Japan.
  • Honda M; Division of Urology, Department of Surgery, Tottori University Faculty of Medicine, Yonago, Japan.
  • Sejima T; Division of Urology, Department of Surgery, Tottori University Faculty of Medicine, Yonago, Japan.
  • Takenaka A; Division of Urology, Department of Surgery, Tottori University Faculty of Medicine, Yonago, Japan.
  • Saito M; Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Japan. Electronic address: saitomo@kochi-u.ac.jp.
Life Sci ; 144: 202-7, 2016 Jan 01.
Article en En | MEDLINE | ID: mdl-26655165
AIMS: We investigated the effects of hypertension and acute blood pressure changes on rats' vesicovascular reflexes (VVRs). MAIN METHODS: Twelve-week-old male Wistar rats and spontaneously hypertensive rats (SHRs) were anesthetized with urethane, and underwent real-time cystometry and blood pressure monitoring. The SHRs were administered nifedipine or valsartan intravenously. The Wistar rats were administered intravenous noradrenaline continuously. The intercontraction intervals, maximum detrusor pressures, blood pressure during the voiding and the urine storage phases, blood pressure elevations associated with the VVRs, and arterial pulses were assessed. Plasma adrenaline and noradrenaline concentrations were measured using HPLC. The degree of atherosclerosis was assessed histologically based on the aortic wall thickness. KEY FINDINGS: Blood pressure elevations associated with the voiding reflexes were significantly lower and intercontraction intervals were significantly shorter in the SHRs compared with the Wistar rats. Although nifedipine and valsartan reduced the systolic blood pressure and noradrenaline increased the systolic blood pressure, they failed to alter the blood pressure elevations associated with the VVRs and the intercontraction intervals. No significant differences occurred with respect to the maximum detrusor pressures among the experimental groups. The reflected waves' shapes were normal in the Wistar rats, but they almost disappeared in the SHRs. The aortic walls were significantly thicker in SHRs compared with those in Wistar rats. SIGNIFICANCE: The blood pressure elevations associated with the VVRs were lower in the SHRs than in the Wistar rats. Acute blood pressure reductions failed to ameliorate the blood pressure elevations associated with VVRs in the SHRs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reflejo / Vasos Sanguíneos Límite: Animals Idioma: En Revista: Life Sci Año: 2016 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reflejo / Vasos Sanguíneos Límite: Animals Idioma: En Revista: Life Sci Año: 2016 Tipo del documento: Article País de afiliación: Japón
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