Serological Measures of Trachoma Transmission Intensity.
Sci Rep
; 5: 18532, 2015 Dec 21.
Article
en En
| MEDLINE
| ID: mdl-26687891
ABSTRACT
Ocular infection with Chlamydia trachomatis can lead to trachoma, a leading infectious cause of blindness. Trachoma is targeted for elimination by 2020. Clinical grading for ocular disease is currently used for evaluating trachoma elimination programs, but serological surveillance can be a sensitive measure of disease transmission and provide a more objective testing strategy than clinical grading. We calculated the basic reproduction number from serological data in settings with high, medium, and low disease transmission based on clinical disease. The data showed a striking relationship between age seroprevalence and clinical data, demonstrating the proof-of-principle that age seroprevalence predicts transmission rates and therefore could be used as an indicator of decreased transmission of ocular trachoma.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
Problema de salud:
2_enfermedades_transmissibles
Asunto principal:
Pruebas Serológicas
/
Chlamydia trachomatis
/
Tracoma
/
Ceguera
Tipo de estudio:
Diagnostic_studies
Límite:
Child
/
Child, preschool
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Female
/
Humans
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Infant
/
Male
Idioma:
En
Revista:
Sci Rep
Año:
2015
Tipo del documento:
Article