New insights into the activation, interaction partners and possible functions of MK5/PRAK.
Front Biosci (Landmark Ed)
; 21(2): 374-84, 2016 01 01.
Article
en En
| MEDLINE
| ID: mdl-26709779
ABSTRACT
MAP kinase-activated protein kinase 5 (MK5) was first described as a downstream target of the p38 MAP kinase pathway leading to its alternative acronym of p38-regulated/activated protein kinase (PRAK). However, since the discovery that MK5 is a bona fide interaction partner of the atypical MAP kinases ERK3 and ERK4 and that this interaction leads to both the activation and subcellular relocalisation of MK5, there has been considerable debate as to the relative roles of these MAPK pathways in mediating the activation and biological functions of MK5. Here we discuss recent progress in defining novel upstream components of the ERK3/ERK4 signalling pathway, our increased understanding of the mechanism by which MK5 interacts with and is activated by ERK3 and ERK4, and the discovery of novel interaction partners for MK5. Finally, we review recent literature that suggests novel biological functions for MK5 in a range of physiological and pathophysiological conditions including neuronal function and cancer.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Serina-Treonina Quinasas
/
Péptidos y Proteínas de Señalización Intracelular
Límite:
Humans
Idioma:
En
Revista:
Front Biosci (Landmark Ed)
Año:
2016
Tipo del documento:
Article
País de afiliación:
Noruega