Clinical relevance of circulating antibodies and B lymphocyte markers in allograft rejection.
Clin Biochem
; 49(4-5): 385-93, 2016 Mar.
Article
en En
| MEDLINE
| ID: mdl-26721422
ABSTRACT
The main challenge in solid organ transplantation remains to tackle antibody-mediated rejection. Our understanding of the antibody-mediated response and the capacity to detect it has improved in the last decade. However, the sensitivity and specificity of the current clinical tools to monitor B cell activation are perfectible. New strategies, including the refinement in the characterization of HLA and non-HLA antibodies, as well as a better understanding of the circulating B cell phenotype will hopefully help to non-invasively identify patients at risk or undergoing antibody-mediated allograft damage. The current review discusses the current knowledge of the B cell biomarkers in solid organ transplantation, with a focus on circulating antibodies and peripheral B cells.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos B
/
Biomarcadores
/
Rechazo de Injerto
/
Isoanticuerpos
Límite:
Humans
Idioma:
En
Revista:
Clin Biochem
Año:
2016
Tipo del documento:
Article
País de afiliación:
Canadá