Effect of long-term antibiotic use on weight in adolescents with acne.
J Antimicrob Chemother
; 71(4): 1098-105, 2016 Apr.
Article
en En
| MEDLINE
| ID: mdl-26782773
ABSTRACT
OBJECTIVES:
Antibiotics increase weight in farm animals and may cause weight gain in humans. We used electronic health records from a large primary care organization to determine the effect of antibiotics on weight and BMI in healthy adolescents with acne.METHODS:
We performed a retrospective cohort study of adolescents with acne prescribed ≥4 weeks of oral antibiotics with weight measurements within 18 months pre-antibiotics and 12 months post-antibiotics. We compared within-individual changes in weight-for-age Z-scores (WAZs) and BMI-for-age Z-scores (BMIZs). We used (i) paired t-tests to analyse changes between the last pre-antibiotics versus the first post-antibiotic measurements; (ii) piecewise-constant-mixed models to capture changes between mean measurements pre- versus post-antibiotics; (iii) piecewise-linear-mixed models to capture changes in trajectory slopes pre- versus post-antibiotics; and (iv) χ(2) tests to compare proportions of adolescents with ≥0.2 Z-scores WAZ or BMIZ increase or decrease.RESULTS:
Our cohort included 1012 adolescents with WAZs; 542 also had BMIZs. WAZs decreased post-antibiotics in all analyses [change between last WAZ pre-antibiotics versus first WAZ post-antibioticsâ=â-0.041 Z-scores (Pâ<â0.001); change between mean WAZ pre- versus post-antibioticsâ=â-0.050 Z-scores (Pâ<â0.001); change in WAZ trajectory slopes pre- versus post-antibioticsâ=â-0.025 Z-scores/6 months (Pâ=â0.002)]. More adolescents had a WAZ decrease post-antibiotics ≥0.2 Z-scores than an increase (26% versus 18%; Pâ<â0.001). Trends were similar, though not statistically significant, for BMIZ changes.CONCLUSIONS:
Contrary to original expectations, long-term antibiotic use in healthy adolescents with acne was not associated with weight gain. This finding, which was consistent across all analyses, does not support a weight-promoting effect of antibiotics in adolescents.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
Problema de salud:
1_sistemas_informacao_saude
Asunto principal:
Peso Corporal
/
Acné Vulgar
/
Antibacterianos
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Antimicrob Chemother
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos