Medusamide A, a Panamanian Cyanobacterial Depsipeptide with Multiple ß-Amino Acids.
Org Lett
; 18(3): 352-5, 2016 Feb 05.
Article
en En
| MEDLINE
| ID: mdl-26784681
ABSTRACT
From a collection of marine cyanobacteria made in the Coiba National Park along the Pacific coast of the Republic of Panama a novel cyclic depsipeptide, given the trivial name medusamide A, has been isolated and fully characterized. Medusamide A contains four contiguous ß-amino acid (2R,3R)-3-amino-2-methylhexanoic acid (Amha) residues. This is the first report of multiple Amha residues and contiguous ß-amino acid residues within a single cyclic peptide-type natural product. Stereochemical assignment of the Amha residues was completed following the synthesis of reference standards for this ß-amino acid and the subsequent derivatization with Marfey's reagent and LC-MS analysis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cianobacterias
/
Depsipéptidos
País/Región como asunto:
America central
/
Panama
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos