Prediction of particle deposition in the lungs based on simple modeling of alveolar mixing.
Respir Physiol Neurobiol
; 225: 8-18, 2016 May.
Article
en En
| MEDLINE
| ID: mdl-26790361
ABSTRACT
A simplified model of particle deposition in the lungs has been developed and implemented, based on the hypothesis that perfect mixing takes place in the alveolar volume of each airway generation. This key idea is combined with purely convective transport along airways, driven by steady alveolar expansion and contraction, and results in an analytically tractable model. Predictions of the model, and in particular pulmonary deposition, are found in very good agreement with detailed benchmark data in the literature for particle diameters d ≥ 0.1 µm. The success of this simple model provides indirect evidence in favor of the role of alveolar mixing in the deposition process.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Alveolos Pulmonares
/
Modelos Cardiovasculares
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Respir Physiol Neurobiol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Grecia