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Perfluorocarbon NVX-108 increased cerebral oxygen tension after traumatic brain injury in rats.
Mullah, Saad H; Saha, Biswajit K; Abutarboush, Rania; Walker, Peter B; Haque, Ashraful; Arnaud, Francoise G; Hazzard, Brittany; Auker, Charles R; McCarron, Richard M; Scultetus, Anke H; Moon-Massat, Paula.
Afiliación
  • Mullah SH; Naval Medical Research Center, NeuroTrauma Department, Silver Spring, MD 20910, USA.
  • Saha BK; Naval Medical Research Center, NeuroTrauma Department, Silver Spring, MD 20910, USA.
  • Abutarboush R; Naval Medical Research Center, NeuroTrauma Department, Silver Spring, MD 20910, USA.
  • Walker PB; Naval Medical Research Center, NeuroTrauma Department, Silver Spring, MD 20910, USA.
  • Haque A; Naval Medical Research Center, NeuroTrauma Department, Silver Spring, MD 20910, USA.
  • Arnaud FG; Naval Medical Research Center, NeuroTrauma Department, Silver Spring, MD 20910, USA; Uniformed Services University of the Health Sciences, Department of Surgery, Bethesda, MD 20814, USA.
  • Hazzard B; Naval Medical Research Center, NeuroTrauma Department, Silver Spring, MD 20910, USA.
  • Auker CR; Naval Medical Research Center, NeuroTrauma Department, Silver Spring, MD 20910, USA; Uniformed Services University of the Health Sciences, Department of Surgery, Bethesda, MD 20814, USA.
  • McCarron RM; Naval Medical Research Center, NeuroTrauma Department, Silver Spring, MD 20910, USA; Uniformed Services University of the Health Sciences, Department of Surgery, Bethesda, MD 20814, USA.
  • Scultetus AH; Naval Medical Research Center, NeuroTrauma Department, Silver Spring, MD 20910, USA; Uniformed Services University of the Health Sciences, Department of Surgery, Bethesda, MD 20814, USA.
  • Moon-Massat P; Naval Medical Research Center, NeuroTrauma Department, Silver Spring, MD 20910, USA.
Brain Res ; 1634: 132-139, 2016 Mar 01.
Article en En | MEDLINE | ID: mdl-26794250
BACKGROUND: Hypoxia is a critical secondary injury mechanism in traumatic brain injury (TBI), and early intervention to alleviate post-TBI hypoxia may be beneficial. NVX-108, a dodecafluoropentane perfluorocarbon, was screened for its ability to increase brain tissue oxygen tension (PbtO2) when administered soon after TBI. METHODS: Ketamine-acepromazine anesthetized rats ventilated with 40% oxygen underwent moderate controlled cortical impact (CCI)-TBI at time 0 (T0). Rats received either no treatment (NON, n=8) or 0.5 ml/kg intravenous (IV) NVX-108 (NVX, n=9) at T15 (15 min after TBI) and T75. RESULTS: Baseline cortical PbtO2 was 28±3 mm Hg and CCI-TBI resulted in a 46±6% reduction in PbtO2 at T15 (P<0.001). Significant differences in time-group interactions (P=0.013) were found when comparing either absolute or percentage change of PbtO2 to post-injury (mixed-model ANOVA) suggesting that administration of NVX-108 increased PbtO2 above injury levels while it remained depressed in the NON group. Specifically in the NVX group, PbtO2 increased to a peak 143% of T15 (P=0.02) 60 min after completion of NVX-108 injection (T135). Systemic blood pressure was not different between the groups. CONCLUSION: NVX-108 caused an increase in PbtO2 following CCI-TBI in rats and should be evaluated further as a possible immediate treatment for TBI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 Problema de salud: 1_doencas_nao_transmissiveis Asunto principal: Corteza Cerebral / Fluorocarburos / Lesiones Traumáticas del Encéfalo / Hipoxia Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Brain Res Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 Problema de salud: 1_doencas_nao_transmissiveis Asunto principal: Corteza Cerebral / Fluorocarburos / Lesiones Traumáticas del Encéfalo / Hipoxia Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Brain Res Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos