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Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1 and MYC, and can be targeted by SYK inhibition.
Köhrer, S; Havranek, O; Seyfried, F; Hurtz, C; Coffey, G P; Kim, E; Ten Hacken, E; Jäger, U; Vanura, K; O'Brien, S; Thomas, D A; Kantarjian, H; Ghosh, D; Wang, Z; Zhang, M; Ma, W; Jumaa, H; Debatin, K-M; Müschen, M; Meyer, L H; Davis, R E; Burger, J A.
Afiliación
  • Köhrer S; Department of Leukemia, Unit 428, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Havranek O; Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Seyfried F; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
  • Hurtz C; Department of Laboratory Medicine, University of California, San Francisco, CA, USA.
  • Coffey GP; Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Kim E; Portola Pharmaceuticals, South San Francisco, CA, USA.
  • Ten Hacken E; Department of Leukemia, Unit 428, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Jäger U; Department of Leukemia, Unit 428, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Vanura K; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
  • O'Brien S; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
  • Thomas DA; Department of Leukemia, Unit 428, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Kantarjian H; Department of Leukemia, Unit 428, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Ghosh D; Department of Leukemia, Unit 428, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Wang Z; Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Zhang M; Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Ma W; Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Jumaa H; Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Debatin KM; Department of Immunology, Ulm University, Ulm, Germany.
  • Müschen M; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
  • Meyer LH; Department of Laboratory Medicine, University of California, San Francisco, CA, USA.
  • Davis RE; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
  • Burger JA; Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Leukemia ; 30(6): 1246-54, 2016 06.
Article en En | MEDLINE | ID: mdl-26847027
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Antígenos de Linfocitos B / Leucemia-Linfoma Linfoblástico de Células Precursoras B / Transducción de Señal / Células Precursoras de Linfocitos B Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Leukemia Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Antígenos de Linfocitos B / Leucemia-Linfoma Linfoblástico de Células Precursoras B / Transducción de Señal / Células Precursoras de Linfocitos B Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Leukemia Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos