Cationic, amphiphilic copolymer micelles as nucleic acid carriers for enhanced transfection in rat spinal cord.

Gwak, So-Jung; Nice, Justin; Zhang, Jeremy; Green, Benjamin; Macks, Christian; Bae, Sooneon; Webb, Ken; Lee, Jeoung Soo

Gwak, So-Jung; Nice, Justin; Zhang, Jeremy; Green, Benjamin; Macks, Christian; Bae, Sooneon; Webb, Ken; Lee, Jeoung Soo.

Afiliación

Gwak SJ; Drug Design, Development, and Delivery (4D) Laboratory, Department of Bioengineering, Clemson University, Clemson, SC 29634-0905, United States.
Nice J; Drug Design, Development, and Delivery (4D) Laboratory, Department of Bioengineering, Clemson University, Clemson, SC 29634-0905, United States.
Zhang J; Drug Design, Development, and Delivery (4D) Laboratory, Department of Bioengineering, Clemson University, Clemson, SC 29634-0905, United States.
Green B; Drug Design, Development, and Delivery (4D) Laboratory, Department of Bioengineering, Clemson University, Clemson, SC 29634-0905, United States.
Macks C; Drug Design, Development, and Delivery (4D) Laboratory, Department of Bioengineering, Clemson University, Clemson, SC 29634-0905, United States.
Bae S; Drug Design, Development, and Delivery (4D) Laboratory, Department of Bioengineering, Clemson University, Clemson, SC 29634-0905, United States.
Webb K; Drug Design, Development, and Delivery (4D) Laboratory, Department of Bioengineering, Clemson University, Clemson, SC 29634-0905, United States.
Lee JS; Drug Design, Development, and Delivery (4D) Laboratory, Department of Bioengineering, Clemson University, Clemson, SC 29634-0905, United States. Electronic address: ljspia@clemson.edu.

Acta Biomater ; 35: 98-108, 2016 Apr 15.

Article en En | MEDLINE | ID: mdl-26873365

Asunto(s)

Micelas; Ácidos Nucleicos/metabolismo; Polímeros/química; Médula Espinal/metabolismo; Tensoactivos/química; Transfección/métodos; Animales; Cationes; Muerte Celular; Línea Celular Tumoral; Supervivencia Celular; Pollos; Ensayo de Cambio de Movilidad Electroforética; Técnicas de Silenciamiento del Gen; Proteínas Fluorescentes Verdes/metabolismo; Ácido Láctico/síntesis química; Ácido Láctico/química; Masculino; Tamaño de la Partícula; Polietileneimina/síntesis química; Polietileneimina/química; Ácido Poliglicólico/síntesis química; Ácido Poliglicólico/química; Copolímero de Ácido Poliláctico-Ácido Poliglicólico; ARN Interferente Pequeño/metabolismo; Ratas Sprague-Dawley; Electricidad Estática

Palabras clave

CNS regeneration; Combinatorial therapy; Nucleic acid delivery; Polymeric micelle

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Médula Espinal / Tensoactivos / Ácidos Nucleicos / Transfección / Micelas Límite: Animals Idioma: En Revista: Acta Biomater Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos

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