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Increased risk of hepatic complications in kidney transplantation with chronic virus hepatitis infection: A nationwide population-based cohort study.
Yu, Tung-Min; Lin, Che-Chen; Shu, Kuo-Hsiung; Chuang, Ya-Wen; Huang, Shih-Ting; Chen, Cheng-Hsu; Wu, Ming-Ju; Chung, Mu-Chi; Chang, Chao-Hsiang; Li, Chi-Yuan; Chung, Chi-Jung.
Afiliación
  • Yu TM; Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan.
  • Lin CC; Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Shu KH; Department of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
  • Chuang YW; Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
  • Huang ST; Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Chen CH; Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Wu MJ; Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Chung MC; Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Chang CH; Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Li CY; Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Chung CJ; Department of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Sci Rep ; 6: 21312, 2016 Feb 19.
Article en En | MEDLINE | ID: mdl-26892933
Data regarding the risk of various liver diseases among different hepatitis viruses in kidney transplantation have not yet been identified.We selected individuals with kidney transplantation (ICD-9-CM V420 or 996.81) from 2000-2009 from the catastrophic illness registry of National Health Insurance Research Database (NHIRD)as the study cohort. The two end-points in the study included overall death, and post-transplant occurrence of hepatic disease. After adjustment for other risk factors, the risk of mortality was increased in patients with HBV infection (N = 352) and with HCV infection (N = 275) compared to those with neither HBV nor HCV infection (N = 3485). In addition,renal transplant recipients with HBV alone,HCV alone, and both with HBV and HCVinfectionrespectively had an approximately 10-fold hazard ratio (HR) = 9.84, 95% confidence interval (CI): 4.61-21.0, 4-fold increased risk (HR = 4.40, 95% CI: 1.85-10.5)and 5-fold increased risk (HR = 4.63, 95% CI: 1.06-20.2)of hepatocellular carcinoma (HCC)compared to those with neither HBV nor HCV infection. Our findings showed a significant risk of de novo liver disease in recipients with hepatitis virus infection. Based on our findings, we reinforce the importance and impact of hepatitis virus in renal transplantation.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 6_ODS3_enfermedades_notrasmisibles Problema de salud: 2_enfermedades_transmissibles / 6_digestive_diseases / 6_kidney_renal_pelvis_ureter_cancer Asunto principal: Trasplante de Riñón / Hepatitis Crónica / Hepatitis Viral Humana Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Sci Rep Año: 2016 Tipo del documento: Article País de afiliación: Taiwán

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 6_ODS3_enfermedades_notrasmisibles Problema de salud: 2_enfermedades_transmissibles / 6_digestive_diseases / 6_kidney_renal_pelvis_ureter_cancer Asunto principal: Trasplante de Riñón / Hepatitis Crónica / Hepatitis Viral Humana Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Sci Rep Año: 2016 Tipo del documento: Article País de afiliación: Taiwán
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