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Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists.
Lotesta, Stephen D; Marcus, Andrew P; Zheng, Yajun; Leftheris, Katerina; Noto, Paul B; Meng, Shi; Kandpal, Geeta; Chen, Guozhou; Zhou, Jing; McKeever, Brian; Bukhtiyarov, Yuri; Zhao, Yi; Lala, Deepak S; Singh, Suresh B; McGeehan, Gerard M.
Afiliación
  • Lotesta SD; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States. Electronic address: slotesta@vitaerx.com.
  • Marcus AP; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Zheng Y; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Leftheris K; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Noto PB; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Meng S; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Kandpal G; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Chen G; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Zhou J; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • McKeever B; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Bukhtiyarov Y; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Zhao Y; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Lala DS; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • Singh SB; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
  • McGeehan GM; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States.
Bioorg Med Chem ; 24(6): 1384-91, 2016 Mar 15.
Article en En | MEDLINE | ID: mdl-26897089
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Espiro / Receptores de Mineralocorticoides / Dibenzoxazepinas / Antagonistas de Receptores de Mineralocorticoides / Indoles Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Espiro / Receptores de Mineralocorticoides / Dibenzoxazepinas / Antagonistas de Receptores de Mineralocorticoides / Indoles Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article