Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy.
Circ Res
; 118(5): 898-906, 2016 Mar 04.
Article
en En
| MEDLINE
| ID: mdl-26941425
ABSTRACT
Mitochondrial reactive oxygen species production has emerged as an important pathological mechanism in myocardial ischemia/reperfusion injury. Attempts at targeting reactive oxygen species by scavenging using antioxidants have, however, been clinically disappointing. This review will provide an overview of the current understanding of mitochondrial reactive oxygen species in ischemia/reperfusion injury. We will outline novel therapeutic approaches designed to directly target the mitochondrial respiratory chain and prevent excessive reactive oxygen species production and its associated pathology. This approach could lead to more effective interventions in an area where there is an urgent need for new treatments.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Daño por Reperfusión Miocárdica
/
Especies Reactivas de Oxígeno
/
Infarto del Miocardio
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Circ Res
Año:
2016
Tipo del documento:
Article