A model of dopamine regulation of glutamatergic synapse on medium size spiny neurons.
Biosystems
; 142-143: 25-31, 2016.
Article
en En
| MEDLINE
| ID: mdl-26957078
ABSTRACT
Spiny neurons of striatum receive glutamatergic synapses on dendritic spines on the neck of which project dopaminergic synapses. Dopamine modulates, by D1 type receptors, the glutamatergic synapses by inducing the phosphorylation of AMPA and NMDA receptors which produces an increased amplitude response. Herein we present a model where, in addition to phosphorylation, the direct modulation by dopamine of the spine resistance can cooperate in producing the observed effect on some of these synapses.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sinapsis
/
Algoritmos
/
Dopamina
/
Modelos Neurológicos
/
Neuronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biosystems
Año:
2016
Tipo del documento:
Article