Intra-axonal protein synthesis in development and beyond.
Int J Dev Neurosci
; 55: 140-149, 2016 Dec.
Article
en En
| MEDLINE
| ID: mdl-26970010
ABSTRACT
Proteins can be locally produced in the periphery of a cell, allowing a rapid and spatially precise response to the changes in its environment. This process is especially relevant in highly polarized and morphologically complex cells such as neurons. The study of local translation in axons has evolved from being primarily focused on developing axons, to the notion that also mature axons can produce proteins. Axonal translation has been implied in several physiological and pathological conditions, and in all cases it shares common molecular actors and pathways as well as regulatory mechanisms. Here, we review the main findings in these fields, and attempt to highlight shared principles.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Axones
/
Regeneración Nerviosa
/
Proteínas del Tejido Nervioso
/
Neuronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Int J Dev Neurosci
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos