miR-340 and ZEB1 negative feedback loop regulates TGF-ß- mediated breast cancer progression.
Oncotarget
; 7(18): 26016-26, 2016 May 03.
Article
en En
| MEDLINE
| ID: mdl-27036021
ABSTRACT
MicroRNAs act as key regulators in carcinogenesis and progression in various cancers. In present study, we explored the role of miR-340 in the breast cancer progression. Our results showed that overexpression of miR-340 inhibits breast cancer cell proliferation and invasion, whereas depletion of miR-340 promotes breast cancer progression. Molecularly, ZEB1 was identified as a target gene of miR-340 and miR-340 suppressed the expression of ZEB1 by directly binding to the 3'-UTR of ZEB1. Furthermore, ZEB1 transcriptionally suppresses miR-340 expression. The negative feedback loop regulated TGF-ß-mediated breast cancer progression. In conclusion, our data suggested that miR-340 acted as a tumor suppressor in breast cancer progression.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Biomarcadores de Tumor
/
Regulación Neoplásica de la Expresión Génica
/
Factor de Crecimiento Transformador beta
/
Retroalimentación Fisiológica
/
MicroARNs
/
Homeobox 1 de Unión a la E-Box con Dedos de Zinc
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Oncotarget
Año:
2016
Tipo del documento:
Article
País de afiliación:
China