Results from the Survey of Antibiotic Resistance (SOAR) 2002-09 in Turkey.
J Antimicrob Chemother
; 71 Suppl 1: i85-91, 2016 May.
Article
en En
| MEDLINE
| ID: mdl-27048585
ABSTRACT
OBJECTIVES:
To investigate changes in antibiotic susceptibility of Streptococcus pneumoniae and Haemophilus influenzae from the Survey of Antibiotic Resistance (SOAR) in community-acquired respiratory tract infections (CA-RTIs) between 2002 and 2009 in Turkey.METHODS:
Previously published SOAR data were used for this analysis. MICs were determined using Etest(®) gradient strips or disc diffusion. Susceptibility against a range of antimicrobial agents was assessed using CLSI breakpoints.RESULTS:
A total of 900 S. pneumoniae isolates were analysed 2002-03 (nâ=â75), 2004-05 (nâ=â301) and 2007-09 (nâ=â524). Four antibiotics were tested consistently throughout and three showed a statistically significant decrease in susceptibility (Pâ<â0.0001) penicillin (74.7% susceptible in 2002-03; 67.8% in 2004-05; and 47.2% in 2007-09); cefaclor (85.3% in 2002-03; 78.7% in 2004-05; and 53.5% in 2007-09) and clarithromycin (85.3% in 2002-03; 82.7% in 2004-05; and 61.9% in 2007-09). Susceptibility to amoxicillin/clavulanic acid did not significantly change (100% in 2002-03; 98.7% in 2004-05; and 97.7% in 2007-09). A total of 930 H. influenzae isolates were analysed 2002-03 (nâ=â133), 2004-05 (nâ=â379) and 2007-09 (nâ=â418). Four antibiotics were also consistently tested ampicillin, amoxicillin/clavulanic acid, clarithromycin and cefaclor. All showed >90% susceptibility, but only cefaclor susceptibility significantly reduced (Pâ<â0.0001) over time (99.2% in 2002-03; 96.3% in 2004-05; and 90.4% in 2007-09).CONCLUSIONS:
In S. pneumoniae from Turkey, there has been a clear statistically significant reduction in susceptibility to key antibiotics since 2002, but not to amoxicillin/clavulanic acid (or amoxicillin). However, susceptibility in H. influenzae remained stable. Continued surveillance is required to monitor future changes in antibiotic susceptibility for CA-RTI bacteria.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
/
4_TD
Problema de salud:
3_zoonosis
/
4_meningitis
/
4_pneumonia
Asunto principal:
Infecciones del Sistema Respiratorio
/
Streptococcus pneumoniae
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Haemophilus influenzae
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Infecciones Comunitarias Adquiridas
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Farmacorresistencia Bacteriana
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Antibacterianos
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
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Child
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Child, preschool
/
Female
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Humans
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Infant
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Antimicrob Chemother
Año:
2016
Tipo del documento:
Article
País de afiliación:
Reino Unido